RNA Interference Technology
From Basic Science to Drug Development
- Edited by: Krishnarao Appasani, GeneExpression Systems, Inc., Massachusetts
- Foreword: Andrew Fire, Stanford University, California
- Foreword: Marshall Nirenberg
- Andrew Fire, Alla Grishok, Jason W. Myers, James E. Ferrell, Nathaniel R. Dudley, Ahmad Z. Amin, Bob Goldstein, Amy E. Pasquinelli, Anna M. Krichevsky, Shih-Chu Kao, Li-Huei Tsai, Kenneth S. Kosik, Queta Boese, William S. Marshall, Anastasia Khvorova, Yerramilli V. B. K. Subrahmanyam, Eric Lader, Ye Ding, Charles E. Lawrence, M. Sohail, G. Doran, Kathy Latham, Vince Pallotta, Lance Ford, Mike Byrom, Mehdi Banan, Po-Tsan Ku, David Brown, Ying Mao, Chris Mello, Laurence Lamarcq, Brad Scherer, Thomas Quinn, Robert Larsen, Marcia Tan, Patty Wong, Andrew Farmer, Oded Singer, Gustavo Tiscronia, Inder M. Verma, M. Sioud, Dag R. Sørrensen, Philipp Hadwiger, Hans-Peter Vornlocher, Frank Buchholz, Federico Calegari, Ralf Kittler, Wieland B. Huttner, Dimitris Bourikas, Thomas Baeriswyl, Rejina Sadhu, Esther T. Stoeckli, Karen E. Stephens, Olivier Zugasti, Nigel J. O'Neil, Patricia Kuwabara, Mark E. Drew, Shawn A. Motyka, James C. Morris, Zefeng Wang, Paul T. Englund, Greg Arndt, Rosa M. Ruiz-Vazquez, Ramachandran Vanitharani, Padmanabhan Chellappan, Claude M. Fauquet, Patrick Lu, Martin C. Woodle, Antje Ostareck-Lederer, Sandra Clauder-Münster, Rolf Thermann, Maria Polycarpou-Schwarz, Marc Gentzel, Matthias Wilm, Joe D. Lewis, Steven A. Haney, Peter Lapan, Jeff Aalfs, Chris Childs, Paul Yaworsky, Chris Miller, Neil J. Clarke, John E. Bisi, Caretha L. Creasy, Michael K. Dush, Kris J. Fisher, John M. Johnson III, Christopher J. Ring, Mark R. Edbrooke, Derek M. Dykxhoorn, Dmitry Samarsky, Margaret Taylor, Mark A. Kay, Anton P. McCaffrey, Lars Zender, Michael Peter Manns, Stefan Kubicka, L. Scherer, John Rossi, Asako Sugimoto, Michael Boutros, Marc Hild, Maria E. Ramos-Nino, Brooke T. Mossman, Howard Y. Chang, Nancy N. Wang, Jen-Tsan Chi, Makoto Miyagishi, Sahohime Matsumoto, Takashi Futami, Hideo Akashi, Krishnarao Appasani, Yasuomi Takagi, Shizuyo Sutou, Takashi Kadowaki, Ryozo Nagai, Kazunari Taira
- ISBN:9780521205177
- Publication date:August 2011
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this 2005 overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
